الشلل الرعاش "مرض باركنسون"

تاريخ النشر: 18/09/2019
عدد المشاهدات: 28
تم نشر الموضوع بواسطة: اعلام قسم تقنيات الاشعة
Parkinson's disease
Dr. Asma'a Hassan Mohamed

Parkinson's disease (PD) is a neurodegenerative disorder of the central nervous system and affects the motor neurons. The disease is named after the English doctor James Parkinson, who published the first detailed description in an essay on the shaking palsy, in 1817. In the onset of the disease , the symptoms include slowness of movement, shaking, rigidity, and difficult of movement, accompanied with abnormal think and behavior. Other known problems include sensory, sleep and emotional problems , The main motor symptoms are collectively called "parkinsonism", or a "parkinsonian syndrome". The cause of Parkinson's disease is thought to be due to the combination between genetic and environmental factors, Those with a family member affected are more likely to get the disease themselves. There is also an increased risk in people exposed to certain pesticides and among those who have had prior head injuries, while there is a reduced risk in tobacco smokers and those who drink coffee or tea. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain. This results in not enough dopamine in this region of the brain. The cause of this cell death is poorly understood, but it involves the build-up of proteins into Lewy bodies in the neurons. Diagnosis of typical cases is mainly based on symptoms, with tests such as neuroimaging used to rule out other diseases. There is no cure for Parkinson's disease. Treatment aims to improve the symptoms. Initial treatment is typically with the antiparkinson medication levodopa (L-DOPA), followed by dopamine agonists when levodopa becomes less effective. As the disease progresses and neurons continue to be lost, these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements. Diet and some forms of rehabilitation have shown some effectiveness at improving symptoms. Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective. Evidence for treatments for the non-movement-related symptoms of this disease, such as sleep disturbances and emotional problems, is less strong.
In 2015, PD affected 6.2 million people and resulted in about 117,400 deaths globally. Parkinson's disease typically occurs in people over the age of 60, of whom about one percent are affected. Males are more often affected than females at a ratio of around 3:2. When it is seen in people before the age of 50, it is called early-onset PD. The average life expectancy following diagnosis is between 7 and 15 years.