داء الذئبة الاحمراري

تاريخ النشر: 17/09/2019
عدد المشاهدات: 32
تم نشر الموضوع بواسطة: اعلام قسم تقنيات الاشعة
Systemic Lupus Erythematous
Dr. Asma'a Hassan Mohamed

Lupus is Latin for "wolf": the disease was so-named in the 13th century as the rash was thought to appear like a wolf's bite. Lupus, also known as ''systemic lupus erythematous'' is an autoimmune disease in which the immune system attack the health body tissues and organs characterized by painful and swollen joints, fever, hair loss, chest pain, mouth ulcers, swollen lymph nodes, felling tired, and red rash in the pattern of butterfly mostly on the face, this symptoms vary in different people and range between simple to sever. The major cause of this disease in not clear, but it is thought to be due to the combination of genetic and environmental conditions for example female sex hormone, sunlight, smoking, vitamin D deficiency which represent the major risk factor associated with this disease. Among identical twins, if one is affected there is a 24% chance the other one will be as well. The mechanism involves an immune response by autoantibodies against a person's own tissues These are most commonly antinuclear antibodies leading to sever inflammation. Diagnosis can be difficult and is based on a combination of symptoms and laboratory tests, There are a number of other kinds of lupus erythematous which include discoid lupus erythematous, neonatal lupus, and sub-acute cutaneous lupus erythematous. Treatments may include NSAIDs, corticosteroids, immunosuppressants, hydroxychloroquine, and methotrexate. Lupus significantly increases the risk of cardiovascular disease with this being the most common cause of death. With modern treatment about 80% of those affected survive more than 15 years. Women with lupus have pregnancies that are higher risk but are mostly successful. Rate of lupus varies between countries from 20 to 70 per 100,000. Women of childbearing age are affected about nine times more often than men. While it most commonly begins between the ages of 15 and 45, a wide range of ages can be affected.